Despite a decade-plus of good deeds and a confessional-style, two-part interview with Oprah Winfrey, the deck is stacked against Lance Armstrong restoring his reputation in any significant way, say industry experts.

For the first time, Armstrong acknowledged that he took a variety of performance-enhancing drugs while winning seven Tour de France titles in an interview that partially aired Thursday night on Winfrey's OWN network. He apologized to the people he called liars after they tried to reveal his doping, even admitting ...